The Primary Information of Tandem Pore Domain Potassium Channel (K2P)
1. Summary
The two-pore-domain or tandem pore domain potassium channels (K2P) are a family of 15 members (K2p1.1, K2p2.1, K2p3.1, K2p4.1, K2p5.1, K2p6.1, K2p7.1, K2p9.1, K2p10.1, K2p12.1, K2p13.1, K2p15.1, K2p16.1, K2p17.1, K2p18.1) that form what is known as leak channels which possess Goldman-Hodgkin-Katz (open) rectification [1].
2. Binding Sites
Ruthenium red binds to the residues (D135 (red sphere) in TREK-2 [2] and E70 (yellow sphere) in TASK-3 [3]) lining the wall of the extracellular ion pathway to inhibit TREK-2 and TASK-3. Mutations of the residues A35, E38 and V42 (black sphere) within the binding site in the extracellular cap of TRAAK significantly increased the TKDC-induced inhibition, indicating that the proposed site was involved in modulating channels. [4] Central cartoon shows the locations of structurally defined K2P small molecule binding sites including the Keystone inhibitor site (white sphere) [5], K2P modulator pocket (grey)[6], Fenestration site (green sphere) [7], Modulatory lipid site (Orange sphere) [8], and Vestibule site (blue) [9].
3. Target List
| ICDB_Pro ID | Protein Name | Organism | Uniport Accession Number | Gene Name |
|---|---|---|---|---|
| ICDB_Pro_0854 | TWiK family of potassium channels protein 18 | Caenorhabditis elegans | Q18120 | twk-18;C24A3.6 |
| ICDB_Pro_0487 | TWiK family of potassium channels protein 7 | Caenorhabditis elegans | P34410 | twk-7;twk-8;F22B7.7 |
| ICDB_Pro_0868 | TWiK family of potassium channels protein 9 | Caenorhabditis elegans | Q23435 | twk-9;ZK1251.8 |
| ICDB_Pro_0072 | TWIK1 (K2P1.1; KCNK1) | Caenorhabditis briggsae | A8X8I4 | twk-12;CBG09670 |